Title: Impact of Established and Newer Anti-epileptic Drugs and their Combination on the Quality of life
Article Number: EC/2014/113
Authors: Ahmed M.A.Y 1, TagEldin Sokrab 2, Mahmoud MA 2
Topic: Clinical Research
Impact of Established and Newer Anti-epileptic Drugs and their Combination on the Quality of life in
People with Epilepsy
The aim was to study and compare the quality of life (QOL) in patients with epilepsy (PWE) treated with established (EAED), newer (NAED) or a combination thereof (CAED) in a developing Gulf state of a growing economy.
The study carried on a prospective cohort of PWE attending the neurology clinic in Hamad General Hospital in Doha, Qatar between 15 October 2009 and 15 April 2011. Phenytoin, carbamazepine, sodium valproate, phenobarbitone, clobazam and clonazepam were the EAEDs and lamotrigine, topiramate and Levetiracetam were the NAEDs drugs available for prescription in our hospital.
Epilepsy patients aged 13 year or more and on AED treatment for at least 6 months provided with a self-completing 32-item questionnaire with graded scales and checklists.
Fifty-three males and 47 females completed the questionnaire. 65% of the participants were below 35 years. Thirty-seven patients were on EAED, 33 on NAED and 30 on CAED. Patients on EAEDs found to have fewer drug side effects than with NAEDs. More seizure, stigmatization and birth abnormalities occurred in patients treated with CAEDs. Good control of seizures was the main determinant of a favorable perception of QOL.
Newer AEDs linked with more side effects than the established with exception side effects of gum, hair loss and suicidal tendency, but they lesser side effects when combined with the established AEDs. The new AEDs were better on psychological wellbeing. However, good seizure control was more important than the type of AED used in rendering improvement in QOL.
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