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Title: Studies on anti-diabetic activity of Cleome viscosa in alloxan-induced diabetic rats

Authors: Boyina Chaya Devi, Chakrapani Ramesh,

Topic: Clinical Research

Abstract:

Cleome viscosa(L.) belonging to family (Capperdiceae),commonly called “Sticky spider flower”, is a terrestrial, annual, erect, aromatic herb. The plant has high medicinal value as it is traditionally used for its antiemetic, wound healing, antimicrobial, hepatoprotective and anti-oxidant properties. The aim of the proposed work is to evaluate the therapeutical potential of Cleome viscosa in alleviating diabetes by assessment of liver and kidney function and lipid profile parameters in alloxan-induced diabetic rats. A significant elevation (P<0.001) of blood glucose, SGPT, SGOT, ALP, urea, uric acid, creatinine and lipid profile in control groups was observed as compared to normal groups. However, there was significant reduction (P<0.001 and P<0.001) in the tested biochemical parameters in both the groups treated with extract as compared to the control group and the effect was compared with the standard drug, Metformin. From these results, it can be concluded that the methanol extract of Cleome viscosa possesses significant ability to reduce the diabetes complications

 

Key words: Cleome viscosa, diabetes, complications, neuropathic pain, lipid profile, liver and kidney function.

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    COMMENT - 1

  • AUGUSTINE ANAYOCHUKWU ONYEAGHALA (Viewer) 30th Jan 2015 - 3:02 AM
    With the advent of genomics, studies using alloxan to induce DM rats is almost becoming obsolete. Rats that are made diabetic using genetic manipulations are widely applied. Nevertheless, considering the cost involved, alloxan induced Dm can be used as a kind of pilot studies before more reliable genetic models can be used.
    • BOYINA CHAYA DEVI (Author) 30th Jan 2015 - 11:08 PM
      Dear Augustine,
      Thanks for reviewing my article and giving valuable in-put to improvise my article.
      Its true and we look into the possibility of pilot studies you have discussed.

  • COMMENT - 2

  • PRANEETH KUMAR (Viewer) 3rd Feb 2015 - 2:36 PM
    Dear chakrapani, your article was very interesting and your way of explanation also very well structured

  • COMMENT - 3

  • BOYINA CHAYA DEVI (Author) 3rd Feb 2015 - 10:45 PM
    Thank you praneeth for reviewing my article and giving comments

  • COMMENT - 4

  • AUGUSTINE ANAYOCHUKWU ONYEAGHALA (Viewer) 8th Feb 2015 - 2:29 AM
    Hi Chakrapani, well done anyways for the efforts.

  • COMMENT - 5

  • BOYINA CHAYA DEVI (Author) 8th Feb 2015 - 9:24 PM
    Thanks